Journal of Nano Drug Science
Submitted: 07 Aug 2018
Accepted: 20 Nov 2018
First published online: 17 Dec 2018
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Journal of Nano Drug Science. 2018;1(1):10-13.
  Abstract View: 1167
  PDF Download: 736

Original Article

Evaluating the Antimicrobial Activity of Zinc Oxide Nanoparticles Against Gram-Positive and Gram-Negative Bacteria in Aquatic Animals

Hadi Mirzaei 1, Mahin Rigi 2 * , Hamid Reza Jahantigh 3

1 Zabol Medicinal Plant Research Center, Zabol University of Medical Sciences, Zabol, Iran
2 Department of Fisheries, Hamoun International Wetland Research Institute, University of Zabol, Zabol, Iran
3 Department of Agriculture, University of Zabol, Zabol, Iran
*Corresponding author: Mahin Rigi, Email: Email:


Introduction: Considering the resistance of bacteria to different types of antibiotics and conventional antimicrobial agents, many studies have been conducted to find new types of effective antimicrobial agents. The purpose of this study was to evaluate the antimicrobial activity of zinc oxide nanoparticles against gram-positive and gram-negative bacteria in aquatic animals.

Methods: Zinc oxide nanoparticles were commercially-purchased. The bacteria studied were purchased in ampoules from the company. Finally, the minimum inhibitory concentration (MIC) and minimum bactericidal concentration were determined by the microdilution method.

Results: According to the results of this study, the maximum inhibitory concentration of zinc oxide nanoparticles was observed against Staphylococcus aureus (1500 μg/mL). The MIC was found to be 187 μg/mL against Shigella dysenteriae and the maximum bactericidal concentration (MBC) was observed against S. aureus, Bacillus cereus and Listeria monocytogenes (1500 μg/mL). However, the minimum bactericidal concentration was observed against Shigella dysenteriae.

Conclusion: The results of this study showed that zinc oxide nanoparticles inhibited the studied bacteria, which increased with increasing inhibitory concentration.

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