Journal of Nano Drug Science
Submitted: 10 Aug 2019
Accepted: 10 Nov 2018
First published online: 17 Dec 2018
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Journal of Nano Drug Science. 2018;1(1):1-4.
  Abstract View: 81
  PDF Download: 83

Original Article

Antimicrobial Activity of Synthesized Nanoparticles Using Prosopis farcta Extract Against Pseudomonas aeruginosa Isolated From Patients

Saeide Saeidi, Elham Javadian, Moslem Birjandi, Fereshteh Javadian *

1 Zabol Medicinal Plant Research Center, Zabol University of Medical Sciences, Zabol, Iran
*Corresponding author: Fereshteh Javadian, Email: Javadian@yahoo.com

Abstract

Introduction: The aim of this study was to evaluate the antimicrobial activity of synthesized nanoparticles using Prosopis farcta extract against Pseudomonas aeruginosa isolated from patients.

Methods: The formation and characterization of silver nanoparticles (AgNPs) were confirmed by UV-Vis spectroscopy, energy-dispersive spectroscopy (EDX), X-ray diffraction (XRD) and transmission electron microscope (TEM). All 12 strains of P. aeruginosa were isolated from urine cultures of hospitalized patients (Amir Al-Momenin hospital, Zabol, South-Eastern Iran) with urinary tract infection, during 2015-2016. The minimum inhibitory concentrations (MIC) were investigated by microdilution method.

Results: The analysis of nanoparticle synthesis showed that the nanotube diameter was 11 mm. The results of this study showed that the MIC of AgNPs was 6.25 ppm, and 2 strains were inhibited in this concentration, while the maximum inhibitory concentration was 100 ppm and 1 strain was inhibited. The maximum bactericidal concentration was 100 ppm, at which 3 strains were lost.

Conclusion: According to the results, nanoparticles produced by P. farcta extract are a good inhibitor of P. aeruginosa and can be used for treating infections caused by P. aeruginosa.

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